According to an article published in CHEST, the journal of the American College of Chest Physicians, acetaminophen use in both children and adults may be associated with an increase in asthma and wheezing.
The authors reviewed 19 different studies that collected data on both asthma and wheezing as well as acetaminophen use. Patients using acetaminophen were significantly more likely to have asthma than those that did not use acetaminophen. Similarly in children, acetaminophen use was more common in children during the year preceding a diagnosis of asthma and more common during the first year of life.
Researchers have several possible, but unproven explanations related to acetaminophen's impact on the pathophysiology of asthma. First, acetaminophen lowers the levels of an antioxidant in the lung called glutathione. Antioxidants, as I have written about previously, in the diet have been associated with less development and symptoms of asthma. Likewise, acetaminophen may allow one of the key enzymes that causes inflammation in asthma, cyclooxygenase, to act unchecked. Finally, acetaminophen may cause increases in IgE levels.
As a parent, I was surprised there were enough children who had not received acetaminophen to even adequately study this. But I was also concerned given how commonly acetaminophen is used to treat fever and pain in kids. Importantly, many other common fever/ pain meds, like ibuprofen, have not been studied to see if similar relationships exist. I doubt many physicians or parents will change how they treat children's fever or pain base on this one study, but it is an interesting topic to keep your eye on.
What do you think?
